In the US, I've taken the long-distance trains a lot. Security is very lax when it comes to trains, so in general, they don't scan or search baggage. There is checked baggage, and baggage you take with you; in the luggage you take with you --- pack what you need accordingly for the span of days you are on the train.
I'm less familiar with having a cabin on the train, but there is space there for you to have your luggage with you, and in general, I believe there is a toilet in each cabin, and window curtains if in need of a change in the cabin.
If in a coach car, which I am much more familiar with, there are many places to store your luggage (above or below your seat, near the ends of many of the cars, and significant areas in the downstairs of two story coach cars). If one is less mobile, handicapped/special-needs seating is on the bottom floor (when booking, I believe one can reserve to sit downstairs). They have many sized restrooms in the downstairs, and always a handicapped restroom. On the upper story there is also often a restroom at the ends of each car. Eastern seaboard trains and some trains in the northwest are one story, but have both handicapped restrooms & larger luggage storage areas at the ends of each car, as well as the usual space above & below one's seat.
If dealing 247, one can keep one's primary travel diaper bag stored w one at their seat, and their extra storage in one's luggage, stored in one of the nearby luggage areas to replenish one's supplies when needed. If one deals more with nighttime IC (that's me), I'd recommend just keeping one's supplies in the main downstairs luggage area and when nighttime comes, simply go downstairs, pull diaper bag from the luggage, change in one of the restrooms, and go back upstairs for the night.
Coach seating is pretty much large, stiff, lazyboy-type chairs that recline, and have foot rests. Bring a light blanket to cover oneself. In the mornings, I recommend getting up before most are flocking to the restrooms, to do what one needs & get ready for the day.
Trash receptacles in the handicapped restrooms are usually substantial. If one is in a smaller restroom for a change, the trash receptacles are definitely smaller, but are labelled for diapers.
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